Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography
Identifieur interne : 000166 ( France/Analysis ); précédent : 000165; suivant : 000167Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography
Auteurs : Torben Haugaard Jensen [Danemark] ; Martin Bech [Allemagne, Suède] ; Tina Binderup [Danemark] ; Arvid Böttiger [Danemark] ; Christian David [Suisse] ; Timm Weitkamp [France] ; Irene Zanette [Allemagne, France] ; Elena Reznikova [Allemagne] ; Jürgen Mohr [Allemagne] ; Fritz Rank [Danemark] ; Robert Feidenhans [Danemark] ; Andreas Kj R [Danemark] ; Liselotte H Jgaard [Danemark] ; Franz Pfeiffer [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Invasive cancer causes a change in density in the affected tissue, which can be visualized by x-ray phase-contrast tomography. However, the diagnostic value of this method has so far not been investigated in detail. Therefore, the purpose of this study was, in a blinded manner, to investigate whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37–83 years) diagnosed with invasive ductal carcinomas were analyzed by X-ray phase-contrast tomography. Ten lymph nodes had metastatic deposits and 7 were benign. The phase-contrast images were analyzed according to standards for conventional CT images looking for characteristics usually only visible by pathological examinations. Histopathology was used as reference. The result of this study was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations to obtain information regarding lymph node involvement previously inaccessible with standard absorption x-ray imaging.
Url:
DOI: 10.1371/journal.pone.0054047
PubMed: 23349784
PubMed Central: 3548812
Affiliations:
- Allemagne, Danemark, France, Suisse, Suède
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Bavière, District de Haute-Bavière, District de Karlsruhe, Hovedstaden, Rhône-Alpes, Île-de-France
- Copenhague, Gif-sur-Yvette, Grenoble, Karlsruhe, Munich
- Université technique de Munich
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Physics, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Binderup, Tina" sort="Binderup, Tina" uniqKey="Binderup T" first="Tina" last="Binderup">Tina Binderup</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Bottiger, Arvid" sort="Bottiger, Arvid" uniqKey="Bottiger A" first="Arvid" last="Böttiger">Arvid Böttiger</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Niels Bohr Institute, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="David, Christian" sort="David, Christian" uniqKey="David C" first="Christian" last="David">Christian David</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Paul Scherrer Institut, Villigen, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Paul Scherrer Institut, Villigen</wicri:regionArea><wicri:noRegion>Villigen</wicri:noRegion></affiliation></author><author><name sortKey="Weitkamp, Timm" sort="Weitkamp, Timm" uniqKey="Weitkamp T" first="Timm" last="Weitkamp">Timm Weitkamp</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Synchrotron Soleil, Gif-sur-Yvette, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Synchrotron Soleil, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>European Synchrotron Radiation Facility, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>European Synchrotron Radiation Facility, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region 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Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Feidenhans, Robert" sort="Feidenhans, Robert" uniqKey="Feidenhans R" first="Robert" last="Feidenhans">Robert Feidenhans</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Niels Bohr Institute, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Kj R, Andreas" sort="Kj R, Andreas" uniqKey="Kj R A" first="Andreas" last="Kj R">Andreas Kj R</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="H Jgaard, Liselotte" sort="H Jgaard, Liselotte" uniqKey="H Jgaard L" first="Liselotte" last="H Jgaard">Liselotte H Jgaard</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept. of Clinical Physiology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Cluster for Molecular Imaging, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pfeiffer, Franz" sort="Pfeiffer, Franz" uniqKey="Pfeiffer F" first="Franz" last="Pfeiffer">Franz Pfeiffer</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Physics, Technische Universität München, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Physics, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Invasive cancer causes a change in density in the affected tissue, which can be visualized by x-ray phase-contrast tomography. However, the diagnostic value of this method has so far not been investigated in detail. Therefore, the purpose of this study was, in a blinded manner, to investigate whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37–83 years) diagnosed with invasive ductal carcinomas were analyzed by X-ray phase-contrast tomography. Ten lymph nodes had metastatic deposits and 7 were benign. The phase-contrast images were analyzed according to standards for conventional CT images looking for characteristics usually only visible by pathological examinations. Histopathology was used as reference. The result of this study was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations to obtain information regarding lymph node involvement previously inaccessible with standard absorption x-ray imaging.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Autier, P" uniqKey="Autier P">P Autier</name></author><author><name sortKey="Boniol, M" uniqKey="Boniol M">M Boniol</name></author><author><name sortKey="Heanue, M" uniqKey="Heanue M">M Heanue</name></author><author><name sortKey="Colombet, M" uniqKey="Colombet M">M Colombet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author><author><name sortKey="Paganelli, G" uniqKey="Paganelli G">G Paganelli</name></author><author><name sortKey="Viale, G" uniqKey="Viale G">G Viale</name></author><author><name sortKey="Luini, A" 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uniqKey="Weitkamp T">T Weitkamp</name></author><author><name sortKey="Zanette, I" uniqKey="Zanette I">I Zanette</name></author><author><name sortKey="David, C" uniqKey="David C">C David</name></author><author><name sortKey="Baruchel, J" uniqKey="Baruchel J">J Baruchel</name></author><author><name sortKey="Bech, M" uniqKey="Bech M">M Bech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="David, C" uniqKey="David C">C David</name></author><author><name sortKey="Weitkamp, T" uniqKey="Weitkamp T">T Weitkamp</name></author><author><name sortKey="Pfeiffer, F" uniqKey="Pfeiffer F">F Pfeiffer</name></author><author><name sortKey="Diaz, A" uniqKey="Diaz A">A Diaz</name></author><author><name sortKey="Bruder, J" uniqKey="Bruder J">J Bruder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weitkamp, T" uniqKey="Weitkamp T">T Weitkamp</name></author><author><name sortKey="Diaz, A" uniqKey="Diaz A">A Diaz</name></author><author><name sortKey="David, C" uniqKey="David C">C David</name></author><author><name sortKey="Pfeiffer, F" uniqKey="Pfeiffer F">F Pfeiffer</name></author><author><name sortKey="Stampanoni, M" uniqKey="Stampanoni M">M Stampanoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Momose, A" uniqKey="Momose A">A Momose</name></author><author><name sortKey="Kawamoto, S" uniqKey="Kawamoto S">S Kawamoto</name></author><author><name sortKey="Koyama, I" uniqKey="Koyama I">I Koyama</name></author><author><name sortKey="Hamaishi, Y" uniqKey="Hamaishi Y">Y Hamaishi</name></author><author><name sortKey="Takai, K" uniqKey="Takai K">K Takai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="David, C" uniqKey="David C">C David</name></author><author><name sortKey="Nohammer, B" uniqKey="Nohammer B">B Nohammer</name></author><author><name sortKey="Solak, Hh" uniqKey="Solak H">HH Solak</name></author><author><name sortKey="Ziegler, E" uniqKey="Ziegler E">E Ziegler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reznikova, E" uniqKey="Reznikova E">E Reznikova</name></author><author><name sortKey="Mohr, J" uniqKey="Mohr J">J Mohr</name></author><author><name sortKey="Boerner, M" uniqKey="Boerner M">M Boerner</name></author><author><name sortKey="Nazmov, V" uniqKey="Nazmov V">V Nazmov</name></author><author><name sortKey="Jakobs, Pj" uniqKey="Jakobs P">PJ Jakobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfeiffer, F" uniqKey="Pfeiffer F">F Pfeiffer</name></author><author><name sortKey="Kottler, C" uniqKey="Kottler C">C Kottler</name></author><author><name sortKey="Bunk, O" uniqKey="Bunk O">O Bunk</name></author><author><name sortKey="David, C" uniqKey="David C">C David</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takei, H" uniqKey="Takei H">H Takei</name></author><author><name sortKey="Kurosumi, M" uniqKey="Kurosumi M">M Kurosumi</name></author><author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T Yoshida</name></author><author><name sortKey="Ishikawa, Y" uniqKey="Ishikawa Y">Y Ishikawa</name></author><author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taras, Ar" uniqKey="Taras A">AR Taras</name></author><author><name sortKey="Hendrickson, Na" uniqKey="Hendrickson N">NA Hendrickson</name></author><author><name sortKey="Lowe, Ka" uniqKey="Lowe K">KA Lowe</name></author><author><name sortKey="Atwood, M" uniqKey="Atwood M">M Atwood</name></author><author><name sortKey="Beatty, Jd" uniqKey="Beatty J">JD Beatty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stampanoni, M" uniqKey="Stampanoni M">M Stampanoni</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Thuring, T" uniqKey="Thuring T">T Thüring</name></author><author><name sortKey="David, C" uniqKey="David C">C David</name></author><author><name sortKey="Roessl, E" uniqKey="Roessl E">E Roessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tapfer, A" uniqKey="Tapfer A">A Tapfer</name></author><author><name sortKey="Bech, M" uniqKey="Bech M">M Bech</name></author><author><name sortKey="Pauwels, B" uniqKey="Pauwels B">B Pauwels</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Bruyndonckx, P" uniqKey="Bruyndonckx P">P Bruyndonckx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stutman, D" uniqKey="Stutman D">D Stutman</name></author><author><name sortKey="Beck, Tj" uniqKey="Beck T">TJ Beck</name></author><author><name sortKey="Carrino, Ja" uniqKey="Carrino J">JA Carrino</name></author><author><name sortKey="Bingham, Co" uniqKey="Bingham C">CO Bingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Gao, K" uniqKey="Gao K">K Gao</name></author><author><name sortKey="Zhu, P" uniqKey="Zhu P">P Zhu</name></author><author><name sortKey="Yuana, Q" uniqKey="Yuana Q">Q Yuana</name></author><author><name sortKey="Huang, W" uniqKey="Huang W">W Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, Z" uniqKey="Qi Z">Z Qi</name></author><author><name sortKey="Zambelli, J" uniqKey="Zambelli J">J Zambelli</name></author><author><name sortKey="Bevins, N" uniqKey="Bevins N">N Bevins</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>France</li><li>Suisse</li><li>Suède</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Hovedstaden</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Copenhague</li><li>Gif-sur-Yvette</li><li>Grenoble</li><li>Karlsruhe</li><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Jensen, Torben Haugaard" sort="Jensen, Torben Haugaard" uniqKey="Jensen T" first="Torben Haugaard" last="Jensen">Torben Haugaard Jensen</name></region><name sortKey="Binderup, Tina" sort="Binderup, Tina" uniqKey="Binderup T" first="Tina" last="Binderup">Tina Binderup</name><name sortKey="Binderup, Tina" sort="Binderup, Tina" uniqKey="Binderup T" first="Tina" last="Binderup">Tina Binderup</name><name sortKey="Bottiger, Arvid" sort="Bottiger, Arvid" uniqKey="Bottiger A" first="Arvid" last="Böttiger">Arvid Böttiger</name><name sortKey="Feidenhans, Robert" sort="Feidenhans, Robert" uniqKey="Feidenhans R" first="Robert" last="Feidenhans">Robert Feidenhans</name><name sortKey="H Jgaard, Liselotte" sort="H Jgaard, Liselotte" uniqKey="H Jgaard L" first="Liselotte" last="H Jgaard">Liselotte H Jgaard</name><name sortKey="H Jgaard, Liselotte" sort="H Jgaard, Liselotte" uniqKey="H Jgaard L" first="Liselotte" last="H Jgaard">Liselotte H Jgaard</name><name sortKey="Kj R, Andreas" sort="Kj R, Andreas" uniqKey="Kj R A" first="Andreas" last="Kj R">Andreas Kj R</name><name sortKey="Kj R, Andreas" sort="Kj R, Andreas" uniqKey="Kj R A" first="Andreas" last="Kj R">Andreas Kj R</name><name sortKey="Rank, Fritz" sort="Rank, Fritz" uniqKey="Rank F" first="Fritz" last="Rank">Fritz Rank</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Bech, Martin" sort="Bech, Martin" uniqKey="Bech M" first="Martin" last="Bech">Martin Bech</name></region><name sortKey="Mohr, Jurgen" sort="Mohr, Jurgen" uniqKey="Mohr J" first="Jürgen" last="Mohr">Jürgen Mohr</name><name sortKey="Pfeiffer, Franz" sort="Pfeiffer, Franz" uniqKey="Pfeiffer F" first="Franz" last="Pfeiffer">Franz Pfeiffer</name><name sortKey="Reznikova, Elena" sort="Reznikova, Elena" uniqKey="Reznikova E" first="Elena" last="Reznikova">Elena Reznikova</name><name sortKey="Zanette, Irene" sort="Zanette, Irene" uniqKey="Zanette I" first="Irene" last="Zanette">Irene Zanette</name></country><country name="Suède"><noRegion><name sortKey="Bech, Martin" sort="Bech, Martin" uniqKey="Bech M" first="Martin" last="Bech">Martin Bech</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="David, Christian" sort="David, Christian" uniqKey="David C" first="Christian" last="David">Christian David</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Weitkamp, Timm" sort="Weitkamp, Timm" uniqKey="Weitkamp T" first="Timm" last="Weitkamp">Timm Weitkamp</name></region><name sortKey="Weitkamp, Timm" sort="Weitkamp, Timm" uniqKey="Weitkamp T" first="Timm" last="Weitkamp">Timm Weitkamp</name><name sortKey="Zanette, Irene" sort="Zanette, Irene" uniqKey="Zanette I" first="Irene" last="Zanette">Irene Zanette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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